Age- and temperature-dependent effects of opioids on medulla oblongata respiratory activity: an in vitro study in newborn rat

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• 作者：Takita ; Koichi ; Herlenius ; Eric ; Lindahl ; Sten G.E. ; Yamamoto ; Yuji
• 关键词：Brainstem ; In vitro ; Newborn rat ; Opioid ; Respiration ; Temperature ; Age
• 刊名：Brain Research
• 出版年：1998
• 出版时间：August 3, 1998
• 年：1998
• 卷：800
• 期：2
• 页码：308-311
• 全文大小：196 K

文摘

Influences of post-natal age (P0–P4) and temperature (22.5°–31.5°C) on the action(s) of opioids on respiratory activities from neonatal rat brainstem–spinal cord preparations were examined in this study. A temperature-dependent μ-opioid receptor effect on respiration was found. In addition, the effect of morphine increased with postnatal age (P0–P4). Hence, age and temperature must be taken into account when performing studies on medullary respiration-related structures using the neonatal rat brainstem–spinal cord preparation.