Novel pyrazolo[3,4-d]pyrimidine with 4-(1H-benzimidazol-2-yl)-phenylamine as broad spectrum anticancer agents: Synthesis, cell based assay, topoisomerase inhibition, DNA intercalation and bovine serum albumin studies

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• 作者：Prinka Singla<sup>asup> ; Vijay Luxami<sup>asup><sup> ; sup><sup>vluxami@thapar.edusup> ; Raja Singh<sup>bsup> ; Vibha Tandon<sup>bsup> ; Kamaldeep Paul<sup>asup><sup> ; sup><sup>kpaul@thapar.edusup>
• 关键词：Pyrazolo[3 ; 4-d]pyrimidine ; Benzimidazole ; Antitumor activity ; ct-DNA ; Bovine serum albumin
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：24-35
• 全文大小：2287 K
• 卷排序：126

文摘

A Series of pyrazolo[3,4-d]pyrimidine-benzimidazole conjugate has been synthesized. Compounds were evaluated in vitro for 60 human cancer cell lines. Four compounds showed excellent antiproliferative activities. Calf thymus-DNA interactions with compounds have been studied. Compounds have also been investigated for bovine serum albumin-binding activity.