Evaluation of Urinary Biomarkers for Radical-Induced Liver Damage in Rats Treated with Carbon Tetrachloride

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• 作者：de Zwart ; Loeckie L. ; Hermanns ; Ralph C. A. ; Meerman ; John H. N. ; Commandeur ; Jan N. M. ; et. al.
• 刊名：Toxicology and Applied Pharmacology
• 出版年：1998
• 出版时间：January, 1998
• 年：1998
• 卷：148
• 期：1
• 页码：71-82
• 全文大小：242 K

文摘

Carbon tetrachloride (CCl₄) is a model compound for inducing free radical damage in liver. In this study 10 biomarkers in rats treated ip with three different single doses of CCl₄(0.25, 0.50, and 1.00 ml/kg body wt) were measured dose and time dependently and compared to evaluate these urinary products as noninvasive biomarkers for radical damage. Eight degradation products of lipid peroxides, namely, formaldehyde, acetaldehyde, acetone, propanal, butanal, pentanal, hexanal, and malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OH-dG) and coproporphyrin III were measured in this study. As general measures of toxicity, several clinical chemical parameters (n