The 5-HT<sub>2C</sub> receptor agonist lorcaserin reduces cocaine self-administration, reinstatement of cocaine-seeking and cocaine induced locomotor activity

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The 5-HT_2C receptor agonist lorcaserin reduces cocaine self-administration, reinstatement of cocaine-seeking and cocaine induced locomotor activity

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作者：Colin Harvey-Lewis^a ; ^{colin.harvey-lewis@camh.ca" class="auth_mail" title="E-mail the corresponding author} ; Zhaoxia Li^a ; Guy A. Higgins^b ; ^c ; Paul J. Fletcher^a ; ^d ; ^e
关键词：5-HT2C receptor ; Lorcaserin ; Cocaine ; Self-administration ; Reinstatement ; Locomotor activity
刊名：Neuropharmacology
出版年：2016
出版时间：February 2016
年：2016
卷：101
期：Complete
页码：237-245
全文大小：1108 K

文摘

•: Lorcaserin, a 5-HT_2C receptor agonist, reduced cocaine self-administration in rats.
•: Lorcaserin reduced reinstatement of cocaine seeking.
•: Lorcaserin blocked cocaine induced hyperactivity.
•: Effects of lorcaserin were blocked by the 5-HT_2C receptor antagonist SB242084.

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