Acute paraquat exposure impairs colonic motility by selectively attenuating nitrergic signalling in the mouse

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Acute paraquat exposure impairs colonic motility by selectively attenuating nitrergic signalling in the mouse

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作者：Lucy Diss ; Sarah Dyball ; Tina Ghela ; Jonathan Golding ; Rachel Morris ; Stephen Robinson ; Rosemary Tucker ; Talia Walter ; Paul Young ; Marcus Allen ; Sara Fidalgo ; Paul Gard ; Jon Mabley ; Bhavik Patel ; Prabal Chatterjee ; Mark Yeoman ; ^{m.s.yeoman@brighton.ac.uk" class="auth_mail" title="E-mail the corresponding author}
关键词：Colon motility ; Colonic migrating motor complex ; Paraquat and nitric oxide
刊名：Autonomic Neuroscience: Basic and Clinical
出版年：2016
出版时间：February 2016
年：2016
卷：195
期：Complete
页码：8-15
全文大小：1080 K

文摘

•: Acute exposure to paraquat significantly impairs colonic transit in the mouse.
•: Paraquat reduces the amplitude of CMMCs and selectively inhibits NO signalling.
•: These effects are not due to changes in oxidative stress, inflammation or Complex 1 activity.

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