Signaling, stress response and apoptosis in pre-diabetes and diabetes: restoring immune balance in mice with alloxan-induced type 1 diabetes mellitus

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Signaling, stress response and apoptosis in pre-diabetes and diabetes: restoring immune balance in mice with alloxan-induced type 1 diabetes mellitus

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作者：Elena G. Novoselova ; Olga V. Glushkova ; Sergey M. Lunin ; ^{lunin@pochta.ru" class="auth_mail" title="E-mail the corresponding author} ; Maxim O. Khrenov ; Tatyana V. Novoselova ; Svetlana B. Parfenyuk ; Evgeny E. Fesenko
关键词：NF-κB ; SAPK/JNK ; Caspase-3 ; Heat-shock proteins ; Cytokines ; Type 1 diabetes ; Thymulin ; IKK Inhibitor XII ; Antioxidants
刊名：International Immunopharmacology
出版年：2016
出版时间：February 2016
年：2016
卷：31
期：Complete
页码：24-31
全文大小：1429 K

文摘

•: Distinct patterns of changes in the immunity were shown in pre-diabetic and diabetic mice in alloxan-induced diabetes model
•: Pre-diabetes and diabetes resulted in different patterns of plasma cytokine changes
•: NF-kB alternative pathway and TLR4 expression were activated in pre-diabetes, while SAPK/JNK was activated at both stages
•: NF-kB inhibitor, thymulin, or antioxidant decreased immune imbalance in diabetes and pancreatic cell damage in pre-diabetes

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