The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

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The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

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作者：Ryan Ferrao¹ ; ³ ; Heidi J.A. Wallweber¹ ; ³ ; Hoangdung Ho¹ ; Christine Tam¹ ; Yvonne Franke¹ ; John Quinn² ; Patrick J. Lupardus¹ ; ^{lupardus.patrick@gene.com" class="auth_mail" title="E-mail the corresponding author}
刊名：Structure
出版年：2016
出版时间：7 June 2016
年：2016
卷：24
期：6
页码：897-905
全文大小：3394 K

文摘

•: IFNLR1 box1 and box2 motifs are required for stable complex formation with JAK1
•: Crystal structure of JAK1 reveals IFNLR1 box1 binding site in the FERM domain
•: Structure-based mutagenesis reveals IFNLR1 PxxLxF motif is essential for binding
•: Structure of JAK1 with IL10RA box1 indicates conservation among class II receptors

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