Effects and mechanisms of melatonin on neural differentiation of induced pluripotent stem cells

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Effects and mechanisms of melatonin on neural differentiation of induced pluripotent stem cells

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作者：Tao Shu^a ; ¹ ; Tao Wu^b ; ¹ ; Mao Pang^a ; Chang Liu^a ; Xuan Wang^a ; Juan Wang^c ; Bin Liu^a ; Limin Rong^a ; ^{ronglm21@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Induced pluripotent stem cells ; Melatonin ; Neuronal differentiation ; Membrane receptor ; AKT
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：3 June 2016
年：2016
卷：474
期：3
页码：566-571
全文大小：1160 K

文摘

•: Melatonin promoted the neural differentiation of iPSCs.
•: Luzindole or LY294002 declined the melatonin-induced increase.
•: These processes were modulated by AKT pathway through melatonin receptor.

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