Differential impact of type-1 and type-2 diabetes on control of heart rate in mice

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Differential impact of type-1 and type-2 diabetes on control of heart rate in mice

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作者：Catherine L. Stables^a ; David S. Auerbach^b ; Steven E. Whitesall^c ; Louis G. D'Alecy^c ; Eva L. Feldman^a ; ^{efeldman@umich.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：BP ; blood pressure ; CO ; cardiac output ; FFT ; fast fourier transform ; FS ; fractional shortening ; HF ; high frequency ; HR ; heart rate ; HRV ; heart rate variability ; IVS ; inter-ventricular septum ; LF ; low frequency ; LV ; left ventricle ; LVIDd ; LV internal diameter in diastole ; LVIDs ; LV internal diameter in systole ; LVPW ; LV posterior wall ; MV A ; mitral valve A velocity ; MV E ; mitral valve E velocity ; pNN6 ; percentage of RR intervals differing by more than 6 ; ms ; PW ; pulse wave ; RMSSD ; root mean s
刊名：Autonomic Neuroscience: Basic and Clinical
出版年：2016
出版时间：January 2016
年：2016
卷：194
期：Complete
页码：17-25
全文大小：1194 K

文摘

•: Heart rate (HR) autonomic control assessed in T1 (STZ) + T2 (db/db) diabetic mice.
•: db/db mice had altered circadian pattern of both HR and sympathetic control of HR.
•: STZ mice had reduced HR and reduced sympathetic control of HR.
•: HR response to stress and exercise was blunted in both models.
•: Consider time of day and stress levels when assessing autonomic control of HR.

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