Essential thrombocythemia with myelofibrosis transformed into acute myeloid leukemia with der(1;15)(q10;q10): case report and literature review

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• 作者：Khalil M. Charafeddine ; Rami A. Mahfouz ; Ghazi S. Zaatari ; Georges Y. Ibrahim ; Samar A. Muwakkit ; Nada D. Najm ; Chantal G. Farra
• 刊名：Cancer Genetics and Cytogenetics
• 出版年：2010
• 出版时间：1 July 2010
• 年：2010
• 卷：200
• 期：1
• 页码：28-33
• 全文大小：193 K

文摘

Translocations involving chromosomes 1 and 15 are uncommon in hematologic malignancies. So far, only 42 cases have been reported with t(1;15) as a reciprocal or complex chromosomal abnormalities. We herein report the first case in the literature, to our knowledge, of a 44-year-old female with essential thrombocythemia and severe myelofibrosis who developed acute myeloid leukemia (AML-M4) with der(1;15)(q10;q10) after 13 years of treatment. In addition, we reviewed the literature for all up-to-date published cases with t(1;15).