刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:1 January 2017
年:2017
卷:482
期:1
页码:50-56
全文大小:681 K
卷排序:482
文摘
Peptidylarginine deiminases (PADs) were induced by hypoxia in malignant glioma cells. PADs mRNA levels were up-regulated in a HIF-1-dependent manner. The induced PADs citrullinated the cell-derived proteins when tested in the lysates. Multiple proteins citrullinated by hypoxia-induced PADs were identified. An extracellular domain of VEGFR2 was citrullinated by human PAD2.
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