Co-loaded paclitaxel/rapamycin liposomes: Development, characterization and in vitro and in vivo evaluation for breast cancer therapy

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Co-loaded paclitaxel/rapamycin liposomes: Development, characterization and in vitro and in vivo evaluation for breast cancer therapy

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作者：Josimar O. Eloy^a ; ^c ; ; Raquel Petrilli^a ; ^c ; José ; Fernando Topan^a ; Heriton Marcelo Ribeiro Antonio^b ; Juliana Palma Abriata Barcellos^a ; Deise L. Chesca^b ; Luciano Neder Serafini^b ; Daniel G. Tiezzi^b ; Robert J. Lee^c ; Juliana Maldonado Marchetti^a ; ^{jmarchet@usp.br" class="auth_mail" title="E-mail the corresponding author} ; ^{joeloy_fcfrp@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author}
关键词：Liposomes ; Co-loading ; Paclitaxel ; Rapamycin ; Breast cancer
刊名：Colloids and Surfaces B: Biointerfaces
出版年：2016
出版时间：1 May 2016
年：2016
卷：141
期：Complete
页码：74-82
全文大小：2108 K

文摘

•: Liposomes loaded with paclitaxel and rapamycin were prepared.
•: Paclitaxel and rapamycin acted synergistically against 4T1 breast cancer cells.
•: Co-loaded liposome better controlled in vivo tumor growth.

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