The application of multiple analyte adduct formation in the LC-MS³ analysis of valproic acid in human serum

详细信息    查看全文

• 作者：Marek Dziadosz ^{analytiker@chemist.com Dziadosz.Marek@mh-hannover.de}
• 关键词：Adduct formation ; Adduct fragmentation ; Valproic acid ; VPA ; LC&ndash ; MS3
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：1040
• 期：Complete
• 页码：159-161
• 全文大小：345 K
• 卷排序：1040

文摘

LC–MS3 quantification of valproic acid was performed. Analyte adduct formation with the components of the mobile phase was used. A multiple analyte adduct with sodium acetate generated the MS3 mass transition. Protein precipitation was applied as sample preparation method. The advantage of analyte adducts in LC–MSn was discussed.