Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by β-amyloid oligomers in an acute mouse model of Alzheimer’s disease

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• 作者：Claudia Balducci^a ; ¹ ; ^{claudia.balducci@marionegri.it} ; Angelisa Frasca^a ; ¹ ; ^{angelisa.frasca@gmail.com} ; Margherita Zotti^a ; ¹ ; ^{margheritazotti@virgilio.it} ; Pietro La Vitola^a ; ^{pietro.lavitola@marionegri.it} ; Emanuela Mhillaj^b ; ^{emanuela.mhillaj@uniroma1.it} ; Emanuele Grigoli^a ; ^{e.grigoli89@gmail.com} ; Martina Iacobellis^a ; ^{m.iacobellis1@campus.unimib.it} ; Federica Grandi^a ; ^{federica.grandi@guest.marionegri.it} ; Massimo Messa^c ; ^{massimo.messa@humanitasresearch.it} ; Laura Colombo^c ; ^{laura.colombo@marionegri.it} ; Monica Molteni^d ; ^{monicamolteni65@gmail.com} ; Luigia Trabace^e ; ^{luigia.trabace@unifg.it} ; Carlo Rossetti^d ; ^{Carlo.Rossetti@uninsubria.it} ; Mario Salmona^c ; ^{mario.salmona@marionegri.it} ; Gianluigi Forloni^a ; ^{gianluigi.forloni@marionegri.it}
• 关键词：Alzheimer&rsquo ; s disease ; Beta-amyloid oligomers ; Memory impairment ; Novel object recognition test ; Neuroinflammation ; Pro-inflammatory cytokines ; IL-1β ; IL-1β receptor antagonist ; Indomethacin ; Toll-like receptor 4
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：188-197
• 全文大小：1799 K
• 卷排序：60

文摘

An ICV injection of AβO impairing memory leads also to a rapid glial activation. Anti-inflammatory drugs prevent the AβO-mediated memory impairment. AβO-mediated effects are abolished by TLR4 antagonist or in TLR4−/− mice. Concluding, TLR4-mediated glial activation is involved in AβO-induced memory impairment.