A new approach to the rapid separation of isomeric compounds in a Silybum marianum extract using UHPLC core-shell column with F5 stationary phase

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• 作者：Jakub Fibigr ; Dalibor &Scaron ; atí ; nský ; ; ^{satinsky@faf.cuni.cz} ; Petr Solich
• 关键词：Silymarin ; Herbal tea ; UHPLC ; Core-shell columns ; Pentafluorophenyl stationary phase ; Separation of isomers
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：203-213
• 全文大小：1403 K
• 卷排序：134

文摘

The method for separation of diastereoisomeric flavonolignans was developed. Method shows short time (10 min) of analysis and reliability for routine quality control. Quality control of Silybum marianum herbal extracts showed variable results. The method shows unique selectivity of F5 stationary phase for separation of silymarin isomers.