Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

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• 作者：Marijana Hranjec ; Kristina Starč ; ević ; S ; ra Kraljević ; Pavelić ; Pero Luč ; in ; Kreš ; imir Pavelić ; Grace Karminski Zamola
• 关键词：Benzimidazoles ; Schiff bases ; Antiproliferaive evaluation ; UV/Vis and fluorescence spectroscopy
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：46
• 期：6
• 页码：2274-2279
• 全文大小：205 K

文摘

A series of novel benzimidazole substituted Schiff bases were synthesized by reaction of aromatic aldehydes with corresponding 2-aminobenzimidazoles. Their structure has been studied by ¹H and ¹³C NMR, IR and UV/Vis spectroscopy.

Majority of prepared Schiff bases were tested on their antiproliferative activity in vitro and exerted non-specific antiproliferative activity on the tested cell lines at the highest tested concentration. Compounds 18 and 19 exerted the strongest non-specific antiproliferative effect on all cell lines and a concentration-dependent effect on HeLa and MCF-7 cell lines at micromolar concentrations but simultaneously being highly cytotoxic on human fibroblasts as well.