Synthesis, characterization, cytotoxicity and antiangiogenic activity of copper(II) complexes with 1-adamantoyl hydrazone bearing pyridine rings

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Synthesis, characterization, cytotoxicity and antiangiogenic activity of copper(II) complexes with 1-adamantoyl hydrazone bearing pyridine rings

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作者：Marko V. Rodić^a ; Vukadin M. Leovac^a ; ^{vukadin.leovac@dh.uns.ac.rs" class="auth_mail" title="E-mail the corresponding author} ; Ljiljana S. Jovanović^a ; Vojislav Spasojević^b ; Milan D. Joksović^c ; Tatjana Stanojković^d ; Ivana Z. Matić^d ; Ljiljana S. Vojinović-Je&scaron ; ić^a ; Violeta Marković^c
关键词：Hydrazones ; Copper(II) complexes ; Caspase-3 ; Angiogenesis ; Physico-chemical characterization
刊名：European Journal of Medicinal Chemistry
出版年：2016
出版时间：10 June 2016
年：2016
卷：115
期：Complete
页码：75-81
全文大小：1122 K

文摘

•: Three novel copper(II) complexes with hydrazine ligand were synthesized.
•: The complexes have good cytotoxic effect.
•: The cytotoxic complexes induce apoptosis in the caspase 3-dependent manner.
•: All three complexes exhibit moderate antiangiogenic activity.

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