Engineering peripheral nerve repair

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• 作者：Laura M Marquardt ; Shelly E Sakiyama-Elbert
• 刊名：Current Opinion in Biotechnology
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：24
• 期：5
• 页码：887-892
• 全文大小：483 K

文摘

Current approaches for treating peripheral nerve injury have resulted in promising, yet insufficient functional recovery compared to the clinical standard of care, autologous nerve grafts. In order to design a construct that can match the regenerative potential of the autograft, all facets of nerve tissue must be incorporated in a combinatorial therapy. Engineered biomaterial scaffolds in the future will have to promote enhanced regeneration and appropriate reinnervation by targeting the highly sensitive response of regenerating nerves to their surrounding microenvironment.