IKKα inibition by a glucosamine derivative enhances Maspin expression in osteosarcoma cell line

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• 作者：Martina Leopizzip>ap>p> ; p>p>1p> ; Rossana Cocchiolap>bp>p> ; p>p>1p> ; Edoardo Milanettip>cp> ; Domenico Raimondop>dp> ; Laura Politip>bp> ; Cesare Giordanop>ep> ; Roberto Scandurrap>bp> ; Anna Scotto d'Abuscop>bp>p> ; p>p>anna.scottodabusco@uniroma1.itp>
• 关键词：IKKα ; Maspin ; Osteosarcoma ; Glucosamine-derivatives ; Cell invasiveness
• 刊名：Chemico-Biological Interactions
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：262
• 期：Complete
• 页码：19-28
• 全文大小：1810 K
• 卷排序：262

文摘

NCPA is a glucosamine derivative able to counteract inflammatory pathways. NCPA inhibits IKKα nuclear translocation inducing Maspin production. NCPA decrease β1 Integrin and MMP-9 and -13. NCPA inhibits cell migration in osteosarcoma cell line 143B.