Epigenetics: A New Model for Intracellular Parasite-Host Cell Regulation

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• 作者：W. Robert McMaster¹ ; ^{robm@mail.ubc.ca" class="auth_mail" title="E-mail the corresponding author} ; Charlotte J. Morrison¹ ; Michael S. Kobor²
• 关键词：Leishmania ; Toxoplasma ; Theileria ; epigenetics ; DNA methylation ; histone modification ; ncRNA ; exosomes.
• 刊名：Trends in Parasitology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：32
• 期：7
• 页码：515-521
• 全文大小：1115 K

文摘

Intracellular protozoan parasites are an extremely important class of pathogens that cause a spectrum of diseases in human and animal hosts. There is a growing body of evidence suggesting that protozoan parasites, like other prokaryotic and viral pathogens, manipulate host cells via epigenetic modifications of the host genome that alter transcription and corresponding signaling pathways. In light of these data, we examine the role of epigenetics in downregulation of host macrophages by Leishmania that could potentially lead to a permanent state of inactivation, thus favoring pathogen survival and disease progression.