Laryngeal mucus hypersecretion is exacerbated after smoking cessation and ameliorated by glucocorticoid administration

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• 作者：Rumi Ueha^a ; ^{ruu1025@yahoo.co.jp} ; Satoshi Ueha^b ; Kenji Kondo^a ; Takaharu Nito^a ; Yoko Fujimaki^a ; Hironobu Nishijima^a ; Koichi Tsunoda^c ; Francis H.W. Shand^b ; Kouji Matsushima^b ; Tatsuya Yamasoba^a
• 关键词：Cigarette smoking ; Smoking cessation ; Laryngeal secretion ; Inflammatory cytokines ; Glucocorticoid treatment
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：265
• 期：Complete
• 页码：140-146
• 全文大小：2194 K
• 卷排序：265

文摘

Cigarette smoke solution (CSS) induces laryngeal mucus hypersecretion. Short-term smoking cessation further exacerbates mucus hypersecretion with the upregulation of inflammatory cytokines. Long-term smoking cessation is effective to suppress mucus hypersecretion and inflammation. Triamcinolone suppresses this inflammation and CSS-induced laryngeal mucus hypersecretion.