Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains

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Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains

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作者：Fahu He¹ ; ⁵ ; Hans-Peter Wollscheid² ; ⁵ ; ⁶ ; Urszula Nowicka¹ ; Matteo Biancospino² ; Eleonora Valentini² ; Aaron Ehlinger³ ; ⁷ ; Filippo Acconcia² ; ⁸ ; Elisa Magistrati² ; Simona Polo² ; ⁴ ; ^{simona.polo@ifom.eu" class="auth_mail" title="E-mail the corresponding author} ; Kylie J. Walters¹ ; ^{kylie.walters@nih.gov" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：22 March 2016
年：2016
卷：14
期：11
页码：2683-2694
全文大小：4158 K

文摘

•: Myosin VI contains a compact structural motif that binds ubiquitin chains
•: MyUb nestles between ubiquitins of K63-linked chains
•: Optineurin interaction requires an expanded MyUb and capacity to bind ubiquitin
•: An isoform-specific helix restricts MyUb binding to ubiquitin chains

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