ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5

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ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5

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作者：Hui-Lung Sun¹ ; ² ; Ri Cui¹ ; JianKang Zhou³ ; Kun-yu Teng⁴ ; Yung-Hsuan Hsiao⁵ ; Kotaro Nakanishi⁶ ; Matteo Fassan¹ ; ⁷ ; Zhenghua Luo¹ ; Guqin Shi⁸ ; Esmerina Tili¹ ; ⁹ ; Huban Kutay⁴ ; Francesca Lovat¹ ; Caterina Vicentini⁷ ; Han-Li Huang¹⁰ ; Shih-Wei Wang¹¹ ; Taewan Kim¹² ; Nicola Zanesi¹ ; Young-Jun Jeon¹ ; Tae Jin Lee¹ ; Jih-Hwa Guh¹³ ; Mien-Chie Hung¹² ; ¹⁴ ; ¹⁵ ; Kalpana Ghoshal⁴ ; Che-Ming Teng² ; Yong Peng³ ; ^{yongpeng@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Carlo M. Croce¹ ; ¹⁶ ; ^{carlo.croce@osumc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：ERK ; Exportin-5 ; Pin1 ; nuclear export ; miRNA ; global downregulation ; liver cancer ; miR-122 ; drug resistance ; microtubule
刊名：Cancer Cell
出版年：2016
出版时间：14 November 2016
年：2016
卷：30
期：5
页码：723-736
全文大小：5077 K

文摘

•: ERK phosphorylation followed by Pin1-mediated isomerization impairs XPO5 activity
•: Downregulation of miR-122 leads to taxol resistance through septin-9 and MARK4
•: XPO5 phosphorylation correlates with poor prognosis in HCC patients
•: Pin1 and MARK4 are potential targets for clinical intervention in liver cancer

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