The impact of cerebrovascular aging on vascular cognitive impairment and dementia

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• 作者：Tuo Yang^a ; Yang Sun^a ; Zhengyu Lu^a ; ^b ; Rehana K. Leak^c ; Feng Zhang ; MD ; PhD^a ; ^d ; ^{zhanfx2@upmc.edu}
• 关键词：Blood-brain barrier ; Hypoperfusion ; Vascular aging ; White matter
• 刊名：Ageing Research Reviews
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：34
• 期：Complete
• 页码：15-29
• 全文大小：2390 K
• 卷排序：34

文摘

Cognitive impairment and dementia are age-related health burden. Neurovascular aging predisposes the brain to reduced blood flow and long-term ischemic injuries, leading to VCID. Diverse pathology underlies VCID, including neuronal loss and white matter injury. Microinfarcts and leukoaraiosis are common. Age-related VCID can be classified into ischemic, hemorrhagic and post-stroke subtypes.