Role of anti-interferon antibodies in breakthrough occurrence during alpha 2a and 2b therapy in patients with chronic hepatitis C

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• 作者：Leroy ; Vincent ; Baud ; Marilyne ; de Traversay ; Caroline ; Maynard-Muet ; Marianne ; Lebon ; Pierre ; et. al.
• 关键词：Anti-interferon antibodies ; Breakthrough ; Chronic hepatitis C ; Recombinant alpha interferon.
• 刊名：Journal of Hepatology
• 出版年：1998
• 出版时间：March, 1998
• 年：1998
• 卷：28
• 期：3
• 页码：375-381
• 全文大小：114 K

文摘

Background/Aims: Alpha interferon induces aminotransferase normalization in about 50 % of patients with chronic viral hepatitis C. However, some patients who initially respond experience a relapse during the treatment period (breakthrough phenomenon). The aim of this study was to evaluate the prevalence of breakthrough and its relationship with the emergence of neutralizing anti-interferon antibodies.