Evolutionary analysis of two complement C4 genes: Ancient duplication and conservation during jawed vertebrate evolution

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• 作者：Mayumi I. Nonaka^a ; ^{nmayumi@bs.s.u-tokyo.ac.jp} ; Tokio Terado^b ; ¹ ; Hiroshi Kimura^b ; Masaru Nonaka^a
• 关键词：Complement C4 ; Classical pathway ; Shark ; Isotype ; Gene duplication ; Evolution
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：68
• 期：Complete
• 页码：1-11
• 全文大小：2175 K
• 卷排序：68

文摘

Two C4 isotypes were found in various jawed vertebrates, including sharks and birds/reptiles. C4 gene duplication occurred in the early days of the jawed vertebrate evolution. Two divergent C4 lineages, termed H-lineage and D-lineage, were found in bony vertebrates. The D-lineage genes were located in a syntenic region outside MHC. In mammals, the D-lineage was lost before speciation, but D-type C4 was regenerated in some species or groups.