Are RECIST criteria sufficient to assess response to therapy in neuroendocrine tumors?

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• 作者：Anna Sowa-Staszczak ; Robert Chrzan ; Dorota Pach ; Agnieszka Stefa¨½ska ; Monika Tomaszuk ; Monika Buziak-Bereza ; Maciej Ko?odziej ; Elwira Przybylik-Mazurek ; Alicja Hubalewska-Dydejczyk
• 关键词：Optimization of PRRT response ; Neuroendocrine tumors ; Peptide receptor radionuclide therapy ; RECIST criteria
• 刊名：Clinical Imaging
• 出版年：2012
• 出版时间：July-August, 2012
• 年：2012
• 卷：36
• 期：4
• 页码：360-364
• 全文大小：386 K

文摘

Material and Methods

Within the group of 47 patients treated with peptide receptor radionuclide therapy (PRRT), four patients were chosen: three with inoperable tumors without liver metastases and one with two lesions in the pancreas and metastases.

Results

In all patients, after PRRT, the changes in the sum of the longest diameters of tumors were between ?1 % and ?21 % , resulting in stable disease reported [strict Response Evaluation Criteria in Solid Tumors (RECIST)]. But the measurements of tumor volume and attenuation in computed tomography and the tumor to nontumor ratio in somatostatin receptor scintigraphy resulted in different response assessments.

Conclusions

The RECIST standard may be not sufficient to properly assess the therapy response in patients with neuroendocrine tumors.