Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling

详细信息    查看全文

• 作者：Yiping Zhu¹ ; ³ ; Shukun Luo² ; ³ ; Yosef Sabo¹ ; Cheng Wang¹ ; Liang Tong² ; ^{ltong@columbia.edu} ; Stephen P. Goff¹ ; ⁴ ; ^{spg1@cumc.columbia.edu}
• 关键词：Myristoylation ; myristoyl-binding protein ; heme oxygenase 2 ; HIV-1 ; retrovirus Gag ; TRAM ; TLR4 ; lipopolysaccharide
• 刊名：Cell Host & Microbe
• 出版年：2017
• 出版时间：8 February 2017
• 年：2017
• 卷：21
• 期：2
• 页码：220-230
• 全文大小：2477 K
• 卷排序：21

文摘

Heme oxygenase 2 (HO-2) binds myristate via a hydrophobic channel HO-2 negatively regulates the functions of myristoylated proteins HO-2 inhibits the production of HIV-1 and MLV virions HO-2 is a negative feedback regulator of TLR4 signaling