On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier

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• 作者：Nicolas Dutzan¹ ; ¹¹ ; Loreto Abusleme¹ ; ¹¹ ; Hayley Bridgeman² ; ³ ; Teresa Greenwell-Wild¹ ; Tamsin Zangerle-Murray² ; ³ ; Mark E. Fife³ ; Nicolas Bouladoux⁴ ; ⁵ ; Holly Linley³ ; Laurie Brenchley¹ ; Kelly Wemyss² ; ³ ; Gloria Calderon¹ ; Bo-Young Hong¹⁰ ; Timothy J. Break⁶ ; Dawn M.E. Bowdish⁷ ; Michail S. Lionakis⁶ ; Simon A. Jones⁸ ; Giorgio Trinchieri⁹ ; Patricia I. Diaz¹⁰ ; Yasmine Belkaid⁴ ; ⁵ ; Joanne E. Konkel² ; ³ ; ¹² ; ^{joanne.konkel@manchester.ac.uk} ; Niki M. Moutsopoulos¹ ; ^{nmoutsopoulos@dir.nidr.nih.gov}
• 关键词：mucosal immunology ; Th17 cells ; IL-17 ; oral immunity ; barrier immunity ; periodontitis ; T cells
• 刊名：Immunity
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：46
• 期：1
• 页码：133-147
• 全文大小：2168 K
• 卷排序：46

文摘

Distinct signals shape the Th17 cell network at the oral barrier Oral barrier Th17 cells develop independently of commensal microbe colonization Physiologic damage through mastication promotes the generation of oral Th17 cells Barrier damage triggers oral Th17-cell-mediated protective immunity and inflammation