Molecular characterization and function of the Prohibitin2 gene in Litopenaeus vannamei responses to Vibrio alginolyticus

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• 作者：Mei-mei Gu^a ; ¹ ; Jing-rong Kong^a ; ¹ ; Di-Huang^a ; Ting Peng^a ; Chen-ying Xie^a ; Kai-yuan Yang^b ; Yuan Liu^a ; ; Wei-Na Wang^a ; ^{wangwn@scnu.edu.cn} ; ^{weina63@aliyun.com}
• 关键词：Litopenaeus vannamei ; PHB2 ; ROS ; p53 ; RNAi ; subcellular localization ; luciferase reporter assays
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：177-188
• 全文大小：1941 K
• 卷排序：67

文摘

A crustacean PHB2 gene (Lv PHB2) was identified in Litopenaeus vannamei. Lv PHB2 is distributed in mitochondria. The transcription of Lv PHB2 after V. alginolyticus challenge indicated that it is involved in pathogen infection. LvPHB2 may play an important role in shrimp innate immunity. The over-expression of Lv PHB2 could activate p53 pathway, which revealed it might participate in apoptosis regulation.