Chlorpromazine inhibits mitochondrial apoptotic pathway via increasing expression of tissue factor

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Chlorpromazine inhibits mitochondrial apoptotic pathway via increasing expression of tissue factor

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作者：Jing Wu^a ; ¹ ; ^{wujing.jing@ems.hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Aimei Li^a ; ¹ ; ^{liaimeiandamy@126.com" class="auth_mail" title="E-mail the corresponding author} ; Yujun Li^a ; ^{Li_Yujun@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaoguang Li^a ; ^{liqian0041@139.com" class="auth_mail" title="E-mail the corresponding author} ; Qingmeng Zhang^a ; ^{qmzhang@126.com" class="auth_mail" title="E-mail the corresponding author} ; Wuqi Song^a ; ^{songwuqi@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Yao Wang^a ; ^{77684507@qq.com" class="auth_mail" title="E-mail the corresponding author} ; James O. Ogutu^a ; ^b ; ^{ogutujim@yahoo.co.uk" class="auth_mail" title="E-mail the corresponding author} ; Jindong Wang^a ; ^{wangjd1110@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jianbo Li^c ; ^{lijianbo136@163.com" class="auth_mail" title="E-mail the corresponding author} ; Renkuan Tang^c ; ^{tangcqum@163.com" class="auth_mail" title="E-mail the corresponding author} ; Fengmin Zhang^a ; ^{fengminzhang@ems.hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Chlorpromazine ; Bcl-2 ; Tissue factor ; Neuronal apoptosis ; Mitochondrial apoptotic pathway
刊名：International Journal of Biochemistry and Cell Biology
出版年：2016
出版时间：January 2016
年：2016
卷：70
期：Complete
页码：82-91
全文大小：3199 K

文摘

•: Less apoptotic cells in CPZ-treated schizophrenic brain than in control.
•: Upregulation of TF and Bcl-2 in CPZ-treated schizophrenics.
•: CPZ treatment increases the levels of Bcl-2 and TF in rat brain.
•: Over-expression of TF increases Bcl-2 levels in C6 cells.
•: CPZ inhibits mitochondrial apoptotic pathway by increasing levels of TF.

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