Kororamide B, a brominated alkaloid from the bryozoan Amathia tortuosa and its effects on Parkinson's disease cells

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• 作者：Yousef Dashti ; Marie-Laure Vial ; Stephen A. Wood ; George D. Mellick ; Catherine Roullier^&dagger ; ; Ronald J. Quinn ; ^{r.quinn@griffith.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 关键词：NMR fingerprint ; Kororamide B ; ECD calculation ; Parkinson's disease
• 刊名：Tetrahedron
• 出版年：2015
• 出版时间：14 October 2015
• 年：2015
• 卷：71
• 期：41
• 页码：7879-7884
• 全文大小：930 K

文摘

NMR metabolite fingerprints of fractions from an extract of the bryozoan Amathia tortuosa allowed identification of three known (1–3) and evidence of a new tribrominated metabolite. The new compound, kororamide B (4), was purified through NMR-guided isolation and the structure assigned by mass and detailed NMR analysis. The absolute configuration of the new compound was established by comparison of the experimental and calculated electronic circular dichroism spectra. The compounds displayed effects on early endosomes when profiled on human olfactory neurosphere-derived cells (hONS) derived from a Parkinson's disease patient using a multidimensional phenotypic assay.