Multifunctional nanoplatform for enhanced photodynamic cancer therapy and magnetic resonance imaging

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• 作者：Yongwei Hao^a ; ^b ; ¹ ; ² ; Bingxiang Zhang^a ; ¹ ; Cuixia Zheng^a ; Mengya Niu^a ; Haochen Guo^a ; Hongling Zhang^a ; Junbiao Chang^b ; ^c ; Zhenzhong Zhang^a ; ^b ; Dr. Lei Wang^a ; ^b ; ^c ; ^{hahalei@139.com} ; Prof. Yun Zhang^a ; ^b ; ² ; ^{zhangyundr@126.com}
• 关键词：Photodynamic therapy ; Magnetic resonance imaging ; Manganese dioxide
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：384-393
• 全文大小：3056 K
• 卷排序：151

文摘

A multifunctional nanoplatform was constructed. The MnO2 coating could increase the O2 supply and GSH consumption. The O2 supply and GSH consumption resulted in enhanced ROS generation. Enhanced PDT efficiency was observed in PLGA/HMME@MnO2 group. The released Mn2+ ions could be the magnetic resonance imaging agents.