A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans

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A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans

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作者：Yang Li¹ ; ⁸ ; ⁹ ; ^{y.li01@umcg.nl" class="auth_mail" title="E-mail the corresponding author} ; Marije Oosting² ; ⁸ ; Sanne P. Smeekens² ; ⁸ ; Martin Jaeger² ; ⁸ ; Raul Aguirre-Gamboa¹ ; Kieu T.T. Le¹ ; Patrick Deelen¹ ; ³ ; Isis Ricañ ; o-Ponce¹ ; Teske Schoffelen² ; Anne F.M. Jansen² ; Morris A. Swertz¹ ; ³ ; Sebo Withoff¹ ; Esther van de Vosse⁴ ; Marcel van Deuren² ; Frank van de Veerdonk² ; Alexandra Zhernakova¹ ; Jos W.M. van der Meer² ; Ramnik J. Xavier⁵ ; ⁶ ; Lude Franke¹ ; Leo A.B. Joosten² ; ^{leo.joosten@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author} ; Cisca Wijmenga¹ ; ⁷ ; ^{c.wijmenga@umcg.nl" class="auth_mail" title="E-mail the corresponding author} ; Vinod Kumar¹ ; ^{v.kumar@umcg.nl" class="auth_mail" title="E-mail the corresponding author} ; Mihai G. Netea² ; ^{mihai.netea@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author}
关键词：cytokine QTL ; cytokine heritability ; innate immune response ; immunogenomics
刊名：Cell
出版年：2016
出版时间：3 November 2016
年：2016
卷：167
期：4
页码：1099-1110.e14
全文大小：6047 K

文摘

•: Host genetics play a major role in inter-individual variability in cytokine responses
•: Identification of 17 novel genome-wide significant cytokine QTLs (cQTLs)
•: cQTLs generally overlap with genomic regions under positive selection
•: Many cQTLs overlap with loci associated with infectious and immune-mediated diseases

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