Fluoridation of synthetic apatite: Effect on the formation of calcium-deficient hydroxyapatite and the properties of porous scaffold

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• 作者：Qunli Rao^a ; ^{qlrao@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xiaoliang Guo^a ; Xiaolan Fan^b ; Bona Dai^a ; Jinsong Wu^c ; Mengan Gong^a ; Chengchei Wu^d
• 关键词：D. Apatite ; Fluoridation ; XRD ; NMR
• 刊名：Ceramics International
• 出版年：2016
• 出版时间：1 February 2016
• 年：2016
• 卷：42
• 期：2
• 页码：3442-3451
• 全文大小：2867 K

文摘

Fluoridated apatite (FHA) has been considered as a promising bone substitute substance due to its promoting cell proliferation and osteoblastic activity. This paper reports on the synthesis of FHAs via chemical precipitation at room temperature with different KF additions. The prepared samples were characterized using various characterization methods. Both lsi0001" class="mathmlsrc">le="View the MathML source" class="mathImg" data-mathURL="/science?_ob=MathURL&_method=retrieve&_eid=1-s2.0-S0272884215020477&_mathId=si0001.gif&_user=111111111&_pii=S0272884215020477&_rdoc=1&_issn=02728842&md5=8515512fb68ce163f79fbc089946d01e">lass="imgLazyJSB inlineImage" height="19" width="36" alt="View the MathML source" title="View the MathML source" src="/sd/grey_pxl.gif" data-inlimgeid="1-s2.0-S0272884215020477-si0001.gif">lass="mathContainer hidden">lass="mathCode">low="scroll">l">Pl">O43- and lsi0002" class="mathmlsrc">le="View the MathML source" class="mathImg" data-mathURL="/science?_ob=MathURL&_method=retrieve&_eid=1-s2.0-S0272884215020477&_mathId=si0002.gif&_user=111111111&_pii=S0272884215020477&_rdoc=1&_issn=02728842&md5=ef7e1ea9e47b7d06688f4317cdc50d77">lass="imgLazyJSB inlineImage" height="19" width="47" alt="View the MathML source" title="View the MathML source" src="/sd/grey_pxl.gif" data-inlimgeid="1-s2.0-S0272884215020477-si0002.gif">lass="mathContainer hidden">lass="mathCode">low="scroll">l">HPO42- ions were found in Fourier transform infrared (FTIR) spectra. X-ray diffraction (XRD) results show that two kinds of CaHPO₄•2H₂O (DCPD1, DCPD2) mixed with FHA were present in the final products at the lower content of KF addition. However, the amount of DCPD decreased as the increment of KF added, which hints that fluoridation distinctly accelerates the reaction of transforming DCPD into FHA. Meanwhile, ³¹P magic angle spinning nuclear magnetic resonance (MAS NMR) spectra indicated that the electron density around P nuclei in FHAs changed with F content. The highly interconnected scaffold with small pores nesting inside large ones had been fabricated by using raw FHA powder and behaved in good bioactivity when examined in simulated body fluid (SBF).