Comparison of glutaraldehyde and carbodiimides to crosslink tissue engineering scaffolds fabricated by decellularized porcine menisci

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• 作者：Shuang Gao^a ; Zhiguo Yuan^b ; ^c ; Weimin Guo^b ; ^c ; Mingxue Chen^b ; ^c ; Shuyun Liu^b ; ^c ; Tingfei Xi^a ; ^d ; ^{tingfeixi@163.com} ; ^{xitingfei@pku.edu.cn} ; Quanyi Guo^b ; ^c ; ^{doctorguo_301@163.com}
• 关键词：EDAC ; 1-ethyl-3-3-dimethyl aminopropyl carbodiimide ; GTA ; glutaraldehyde ; FTIR ; Fourier transform infrared spectroscopy ; SEM ; Scanning Electron Microscope ; ECM ; Extra cellular matrix ; sGAG ; Sulfate glycosaminoglycan ; NHS ; N-hydroxysuccinimide ; DMEM ; Dulbecco's modified eagle medium
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：891-900
• 全文大小：2501 K
• 卷排序：71

文摘

Porous meniscus scaffolds were fabricated using decellularized meniscus tissue. Mechanical properties of meniscus scaffolds were enhanced by chemical crosslinking. The crosslinked scaffold showed enhanced anti-degradation properties. Chondrocytes could infiltrate and proliferate within crosslinked scaffolds.