Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1

详细信息查看全文

作者：Matthew Locke¹ ; ⁴ ; ⁵ ; Essam Ghazaly² ; ⁴ ; Marta O. Freitas¹ ; Mikaella Mitsinga¹ ; Laura Lattanzio³ ; Cristiana Lo Nigro³ ; Ai Nagano¹ ; Jun Wang¹ ; Claude Chelala¹ ; Peter Szlosarek¹ ; Sarah A. Martin¹ ; ^{sarah.martin@qmul.ac.uk" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：9 August 2016
年：2016
卷：16
期：6
页码：1604-1613
全文大小：2234 K

文摘

•: ASS1-deficient tumors become resistant to arginine deprivation via ASS1 re-expression
•: ASS1-deficient cells have decreased levels of acetylated polyamine metabolites
•: Polyamine metabolites are decreased in ASS1-deficient cells upon arginine deprivation
•: ASS1 deficiency is synthetically lethal with inhibition of polyamine metabolism

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.