Protective effect of lithium chloride against hypoglycemia-induced apoptosis in neuronal PC12 cell

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Protective effect of lithium chloride against hypoglycemia-induced apoptosis in neuronal PC12 cell

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作者：Yuzhen Xu^a ; Qian Wang^b ; Dongsheng Li^c ; Zhenghua Wu^c ; Dawei Li^c ; Kaili Lu^a ; Yuwu Zhao^a ; ^{zhao_yuwu2005@126.com" class="auth_mail" title="E-mail the corresponding author} ; Yongning Sun^d
关键词：AD ; Alzheimer&rsquo ; s disease ; AMBMP ; 2-amino-4-(3 ; 4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine ; DMEM ; Dulbecco&rsquo ; s Modified Eagle Medium ; LDH ; lactate dehydrogenase ; LiCl ; Lithium chloride ; NGF ; nerve growth factor ; PBS ; phosphate buffered saline ; PVDF ; polyvinylidene difluoride
刊名：Neuroscience
出版年：2016
出版时间：25 August 2016
年：2016
卷：330
期：Complete
页码：100-108
全文大小：1646 K

文摘

•: 5">We established a hypoglycemia model in neuronal PC12 cell.
•: Hypoglycemia induced increased apoptosis in PC12 cell.
•: 5">Hypoglycemia significantly inhibits the gene/protein expressions of Wnt pathway.
•: LiCl can attenuate hypoglycemia-induced apoptosis in PC12 cells via Wnt pathway.
•: 5">LiCl may be a therapy for reducing neurological damage caused by hypoglycemia.

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