Hazard screening of photo-transformation products from pharmaceuticals: Application to selective β₁-blockers atenolol and metoprolol

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• 作者：Anju Priya Toolaram ^{toolaram@leuphana.de anjutoolaram@yahoo.com} ; Jakob Menz ^{jakob.menz@uni.leuphana.de} ; Tushar Rastogi ^{tushar.rastogi@leuphana.de} ; Christoph Leder ^{cleder@leuphana.de} ; Klaus Kü ; mmerer ; ^{klaus.kuemmerer@uni.leuphana.de} ; Mandy Schneider ^{mschneid@leuphana.de}
• 关键词：ATL ; Atenolol ; ATP(s) ; transformation product(s) of Atenolol ; BCF ; bioconcentration factor ; CA ; chromosome aberration ; DNA ; deoxyribonucleic acid ; DOC ; dissolved organic carbon ; EMA ; ethidium monoazide dye (Nuclei acid dye A) ; HPLC ; high performance liquid chromatography ; LBT ; luminescence bacteria test ; LC-MS ; liquid chromatography-mass spectrometry ; Log Kow ; octanol-water partition coefficient ; MN ; micronucleus ; MTL ; Metoprolol ; MTP(s) ; Transformation product(s) of Metoprolol ; PC ; parent compo
• 刊名：Science of The Total Environment
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：579
• 期：Complete
• 页码：1769-1780
• 全文大小：2065 K
• 卷排序：579

文摘

Photolysis led to incomplete mineralization of parent compounds Bioassays, chemical analytics together with in-silico methods identified hazards Photolysis mixtures were more toxic than the β-blockers. QSAR analysis of transformation products identified diverse mechanisms of toxicity Several photo-TPs predicted to present greater hazards than parent compound