Synthesis and antimicrobial activity of novel arylideneisothiosemicarbazones

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• 作者：Cardia ; Maria Cristina ; Begala ; Michela ; Delogu ; Alessandro ; Maccioni ; Elias ; Plumitallo ; Antonio
• 关键词：Arylideneisothiosemicarbazones ; Antimicrobial ; Structure&ndash ; activity relationships
• 刊名：Il Farmaco
• 出版年：2000
• 出版时间：February, 2000
• 年：2000
• 卷：55
• 期：2
• 页码：93-98
• 全文大小：88.6 K

文摘

Arylidenimidazoles bearing a thioethereal function in the position 2 of the imidazole ring show good antimicrobial activity. We now report on the synthesis and the biological properties of some novel arylidenisothiosemicarbazones, structurally related to the arylideneiminoimidazoles of which they can be considerecd the linear precursors. Particular attention has been put on the influence of structural modifications on the biological activity.