Synthesis and biological evaluation of some differently substituted 9,10-anthracenediones

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• 作者：Cardia ; Maria Cristina ; Begala ; Michela ; DeLogu ; Alessandro ; Maccioni ; Elias
• 关键词：9 ; 10-Anthracenediones ; Amino-acid derivatives ; Topoisomerase II
• 刊名：Il Farmaco
• 出版年：2001
• 出版时间：August 1, 2001
• 年：2001
• 卷：56
• 期：8
• 页码：549-554
• 全文大小：113 K

文摘

9,10-Anthracenedione derivatives are known to exhibit a quite potent anticancer activity. It has also been reported that these compounds can be effectively employed in both antibacterial and antitrypanosomal therapy. Anthraquinones also exhibit some undesirable side effects, like cardiotoxicity. So many interactions seem to demonstrate that 9,10-anthracenediones strongly interact with a number of biological sites. In this paper we wish to report on the synthesis and the pharmaceutical activity of some newly synthesised derivatives containing the anthraquinone pharmacophore.