ZnO-mediated regioselective C-arylsulfonylation of indoles: a facile solvent-free synthesis of 2- and 3-sulfonylindoles and preliminary evaluation of their activity against drug-resistant mutant HIV-1 reverse transcriptases (RTs)

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• 作者：Graziella Tocco ; Michela Begala ; Francesca Esposito ; Pierluigi Caboni ; Valeria Cannas ; Enzo Tramontano
• 关键词：Regioselectivity ; C-Arylfonylation ; Indoles ; Non-nucleoside inhibitor ; HIV-1 RT
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：13 November, 2013
• 年：2013
• 卷：54
• 期：46
• 页码：6237-6241
• 全文大小：1243 K

文摘

A ZnO-mediated one-pot solvent-free protocol for the regioselective C-arylsulfonylation of indoles is described and some novel derivatives were tested on wild type and non-nucleoside inhibitor resistant K103N and Y181C HIV-1 reverse transcriptases (RTs).