A model of dynamic stability of H3K9me3 heterochromatin to explain the resistance to reprogramming of differentiated cells

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• 作者：Charly Jehanno ; Gilles Flouriot ; Pascale Le Goff ; Denis Michel ; ^{denis.michel@live.fr}
• 关键词：Epigenetic mechanism ; H3K9me3 ; SUV39H1 ; Cellular differentiation
• 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1860
• 期：2
• 页码：184-195
• 全文大小：1475 K
• 卷排序：1860

文摘

H3K9me3 heterochromatin is robustly maintained in a dynamical manner. A new role is proposed for the accumulation of SUV39H1/2 enzymes in heterochromatin. The local concentration of SUV39H1/2 can counteract H3K9 demethylation bursts. Chromocenters are envisioned as microdomains specifying local concentrations. The concentrations of free and bound chromatin-modifying enzymes should be functionally distinguished.