<
h4 class=""
h4"">Background
h4>ATP10D belongs to a subfamily of P-type ATPases implicated in p
hosp
holipids translocation from t
he exoplasmic to t
he cytoplasmic leaflet of cellular biological membrane. Previous genome-wide association study (GWAS) identified t
hat a variant in Atp10d gene (rs2351791) associates wit
h serum lipid profile and myocardial infarction. T
he objective of t
his study is to assess t
he effect of t
his variant on at
herosclerosis in Japanese elderly population.<
h4 class=""
h4"">Met
hod
h4>
Consecutive autopsy cases registered in JG-SNP study were recruited (n?=?1536). The samples were pathologically assessed for atherosclerosis using macroscopic examination of the formalin-fixed arteries, and coronary stenotic index (CSI), intracranial atherosclerotic index (ICAI) and pathological atherosclerotic index (PAI), which represent systemic arteries were calculated. The variant rs2351791 (G/T) in Atp10d gene was genotyped by Taqman genotyping assay and association determined.<h4 class=""h4"">Resulth4>
Both CSI and ICAI were significantly higher in GG genotype than GT genotype and TT genotype (p?=?0.003 and p?=?0.001, respectively). Both associations remained significant in minor allele dominant model after adjusting for age, hypertension, diabetes, HDL, smoking and drinking (p?=?0.001 and p?=?0.001, respectively). PAI was not associated with this variant. Consistent with the previous report, plasma HDL cholesterol level was lower in GG genotype compared to GT?+?TT genotypes (p?=?0.001).<h4 class=""h4"">Conclusionh4>
The rs2351791 SNP in the Atp10d gene affects the susceptibility for cardiac and intracranial vascular stenosis in the elderly Japanese population.