Intracellular triggered release of DNA-quaternary ammonium polyplex by ultrasound

详细信息    查看全文

• 作者：Wei-Hao Liao^a ; Ming-Yen Hsiao^b ; ^a ; Chia-Wen Lo^a ; Hui-Shan Yang^d ; Ming-Kuan Sun^c ; Feng-Huei Lin^b ; ^c ; Yung Chang^d ; ^{changyung0307@gmail.com} ; Wen-Shiang Chen^a ; ^b ; ^c ; ^e ; ^{wenshiang@gmail.com}
• 关键词：Gene transfection ; Ultrasound ; Cationic polymer ; Endosomal escape
• 刊名：Ultrasonics Sonochemistry
• 出版年：2017
• 出版时间：May 2017
• 年：2017
• 卷：36
• 期：Complete
• 页码：70-77
• 全文大小：1333 K
• 卷排序：36

文摘

The data could be applied in selective gene therapy with controlled-release by US exposure. The results have potential in many pharmaceutical applications requiring precise temporal and spatial release control. The data offer directions for future investigation of the intracellular trafficking mechanisms of US exposure.