CEACAM1-Mediated Inhibition of Virus Production

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CEACAM1-Mediated Inhibition of Virus Production

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作者：Alon Vitenshtein¹ ; Yiska Weisblum² ; Sebastian Hauka³ ; Anne Halenius⁴ ; Esther Oiknine-Djian² ; Pinchas Tsukerman¹ ; Yoav Bauman¹ ; Yotam Bar-On¹ ; Noam Stern-Ginossar¹ ; Jonatan Enk¹ ; Rona Ortenberg⁵ ; ⁶ ; Julie Tai¹ ; Gal Markel⁵ ; ⁶ ; Richard S. Blumberg⁷ ; Hartmut Hengel⁴ ; Stipan Jonjic⁸ ; Dana G. Wolf² ; Heiko Adler⁹ ; Robert Kammerer¹⁰ ; Ofer Mandelboim¹ ; ^{oferm@ekmd.huji.ac.il" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：14 June 2016
年：2016
卷：15
期：11
页码：2331-2339
全文大小：1692 K

文摘

•: IFI16 and RIG-I sensing of HCMV and influenza viruses induces expression of CEACAM1
•: IRF3 directly binds the CEACAM1 promoter and mediates the induction of CEACAM1
•: CEACAM1 suppresses mTOR activation and virus production in an SHP2-dependent manner
•: CEACAM1 suppresses HCMV spread in human ex vivo organ culture model of infection

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