Davallia bilabiata exhibits anti-angiogenic effect with modified MMP-2/TIMP-2 secretion and inhibited VEGF ligand/receptors expression in vascular endothelial cells

详细信息    查看全文

• 作者：Chun-Ting Liu^a ; ¹ ; Kuo-Wei Bi^a ; ¹ ; Chao-Chun Huang^b ; Hsiao-Ting Wu^a ; Hui-Ya Ho^c ; Jong-Hwei S. Pang^d ; ^e ; ^{jonghwei@mail.cgu.edu.tw} ; Sheng-Teng Huang^f ; ^g ; ^{sheng.teng@yahoo.com}
• 关键词：D. bilabiata ; Davallia bilabiata ; MMPs ; matrix metalloproteinases ; VEGF ; vascular endothelial growth factor ; VEGFR ; vascular endothelial growth factor receptor ; CAM ; chorioallantoic membrane ; TIMP ; tissue inhibitor of metalloproteinase ; RECK ; reversion-inducing cysteine-rich protein with kazal motifs ; qRT-PCR ; real time polymerase chain reaction ; TNF-α ; tumor necrosis factor-α ; IL-1β ; interleukin-1β ; CAMs ; cellular adhesion molecules ; ECM ; extracellular matrix ; RA ; rheumatoid arthritis ; D. formo
• 刊名：Journal of Ethnopharmacology
• 出版年：2017
• 出版时间：20 January 2017
• 年：2017
• 卷：196
• 期：Complete
• 页码：213-224
• 全文大小：3038 K
• 卷排序：196

文摘

D. bilabiata inhibited angiogenesis both in vitro and in vivo. The extracellular MMP-2 activity was reduced by D.bilabiata both in vitro and in vivo dose-dependently. D. bilabiata inhibited MMP-2, and MMP-14 and enhanced TIMP-2 and RECK in mRNA level. D. bilabiata induced the dose-dependent decrease of MMP-2 and increase of TIMP-2 secretion. The gene expressions of VEGF-A, -B, -C, -D and VEGFR-1, -2, -3 were all inhibited by D. bilabiata.