The roles of IP<sub>3</sub> receptor in energy metabolic pathways and reactive oxygen species homeostasis revealed by metabolomic and biochemical studies

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The roles of IP₃ receptor in energy metabolic pathways and reactive oxygen species homeostasis revealed by metabolomic and biochemical studies

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作者：He Wen¹ ; Wen Jun Xu¹ ; Xing Jin ; Sehyun Oh ; Chau Hong Duc Phan ; Jayoung Song ; Sang Kook Lee ; Sunghyouk Park ; ^{psh@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：IP3R ; inositol 1 ; 4 ; 5-trisphosphate receptors ; OPLS-DA ; orthogonal projections to latent structure-discriminant analysis ; DHR123 ; dihydrorhodamine 123 ; DCFDA ; diacetyldichlorofluorescein ; BrdU ; 5-Bromo-2&prime ; -deoxy-uridine ; MnTBAP ; Mn(III) tetrakis (4-benzoic acid) porphyrin chloride ; XeB ; Xestospongin B
刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
出版年：2015
出版时间：November 2015
年：2015
卷：1853
期：11
页码：2937-2944
全文大小：877 K

文摘

•: The energy metabolism of IP₃R WT and KO cells is very different.
•: IP₃R KO exhibited higher energy charge, lower NADPH, and higher general ROS levels.
•: The IP₃R KO cells feature slower growth rate, possibly due to the higher ROS level rather than AMPK-mediated pathways.

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