On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments

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On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments

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作者：Marco Pirazzini^a ; Domenico Azarnia Tehran^a ; Oneda Leka^a ; Giulia Zanetti^a ; Ornella Rossetto^a ; Cesare Montecucco^a ; ^b ; ^{cesare.montecucco@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Botulinum neurotoxin isoforms ; Clostridia ; Duration of neuroparalysis ; Endocytosis ; Presynaptic binding ; Translocation
刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
出版年：2016
出版时间：March 2016
年：2016
卷：1858
期：3
页码：467-474
全文大小：1162 K

文摘

•: Provides a comprehensive review of membrane translocation of botulinum neurotoxins
•: Presents a parallel analysis of possible models for the membrane translocation
•: Discusses a novel model
•: Suggests novel experiments to test current models

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