Treatment with anti-RANKL antibody reduces infarct size and attenuates dysfunction impacting on neutrophil-mediated injury

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Treatment with anti-RANKL antibody reduces infarct size and attenuates dysfunction impacting on neutrophil-mediated injury

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作者：Federico Carbone^a ; ¹ ; Lindsey A. Crowe^b ; ¹ ; Aline Roth^a ; Fabienne Burger^a ; Sé ; bastien Lenglet^a ; Vincent Braunersreuther^c ; Karim J. Brandt^a ; Alessandra Quercioli^a ; Franç ; ois Mach^a ; Jean-Paul Vallé ; e^b ; Fabrizio Montecucco^d ; ^{Fabrizio.montecucco@unige.it" class="auth_mail" title="E-mail the corresponding author}
关键词：Myocardial infarction ; Inflammation ; Neutrophils
刊名：Journal of Molecular and Cellular Cardiology
出版年：2016
出版时间：May 2016
年：2016
卷：94
期：Complete
页码：82-94
全文大小：2019 K

文摘

•: RANKL inhibition before reperfusion improves infarct size in mice.
•: RANKL inhibition before reperfusion improves cardiac function in mice.
•: RANKL-induced injury is associated with neutrophil degranulation and migration.

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